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Does methotrexate take pain away? Methotrexate is one of the mainstays of treatment for inflammatory forms of arthritis, including rheumatoid arthritis (RA) psoriatic arthritis and juvenile idiopathic arthritis, because it not only reduces pain and swelling, but it can actually slow joint damage and disease progression over time.
Is it better to take methotrexate in the morning or at night? Methotrexate can cause gastrointestinal upset, fatigue, or even flu-like symptoms in some people. If it occurs, it is usually the day or two after you have taken your methotrexate. Take your methotrexate around supper time, so its effect may be gone by morning. The injection route may be more tolerable than tablets.
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