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How do Biologics work for psoriatic arthritis? Patients in the study took either Remicade (infliximab) or Simponi (golimumab) for their psoriatic arthritis. These biologics work by blocking a pro-inflammatory protein called tumor necrosis factor-alpha (TNF-alpha). It boils down to being in better health when you start your biologic. Does psoriatic arthritis get worse over time? Psoriatic arthritis tends to be worse in the morning. It's associated with joint swelling and decreased range of motion, and tends to improve as the day goes on, in contrast to osteoarthritis, which tends to get worse as the day goes on. What does rheumatoid arthritis pain feel like? In most cases, the pain occurs on both sides of the body. Symmetric pain in multiple joints is what makes RA different from other types of arthritis. For example, you'll feel pain in both left and right wrists, hands, and knees. If you have RA, joint pain can range from mild to moderate or severe.
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